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流行病学调查的结果,显示在炼镍工人中肺癌及鼻腔癌的发生率都有增长的趋势。据[Pederson 1953～1971调查挪威炼镍工厂1916人中,证实呼吸道癌的发生率确有上升。若将该组工人中呼吸道癌的患者和所有死亡者及挪威癌症统计中心的数字对比,发现在烧锻、冶炼和电解车间的工人中,已发现和预期的肺癌发生比率为7∶1,鼻腔癌为40∶1。作者认为癌的发生率增加,是由于工厂空气中镍元素的污染。鼻腔癌在形成之前,先出现上皮的癌前改变,因而有可能施行癌前普查。本文资料乃根据在挪威炼镍厂工人以及两对照组人群中进行鼻腔普查,并从鼻中甲前端粘膜咬取活检,对粘膜的组织学检查的结果加以分析。
The results of the epidemiological survey showed that the incidence of lung cancer and nasal cancer among nickel-refining workers tended to increase. According to [Pederson 1953-1971 survey of 1916 people in Norway nickel refining plant, confirmed the incidence of respiratory cancer does rise. Comparing the numbers of patients with respiratory cancer in this group of workers to all those killed and the Norwegian Cancer Statistics Center, it was found that the incidence of lung cancer was found to be expected to be 7: 1 among workers in the burn-making, smelting and electrolysis plants, The cancer is 40: 1. The author believes that the increased incidence of cancer is due to the pollution of nickel in plant air. Before the formation of nasal cancer, epithelial pre-cancerous changes occur, which may be implemented before the cancer screening. The data for this article is based on a nasal census conducted in Norwegian nickel refineries and two control groups and biopsies from the mucosa of the nasal septum to analyze the results of the mucosal histological examination.