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目的分析妊娠期肝内胆汁淤积症(ICP)产妇血清脂类、载脂蛋白指标检测结果。方法连续选择近期入院分娩的29例ICP产妇,均接受了血脂(总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白)和载脂蛋白(A和B)指标检测,并与同期住院正常怀孕产妇(对照组33例)进行比较。结果 ICP组血清总胆固醇、甘油三酯、低密度脂蛋白和载脂蛋白B浓度均明显高于对照组,而高密度脂蛋白和载脂蛋白B则明显低于对照组(P均<0.05~0.01)。结论 ICP产妇存在明确的血清脂类和载脂蛋白指标异常。
Objective To analyze the serum lipids and apolipoprotein indexes of pregnant women with intrahepatic cholestasis of pregnancy (ICP). Methods A total of 29 consecutive pregnant women who were admitted to hospital for delivery were enrolled in the study. Blood lipids (total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein) and apolipoproteins (A and B) Normal pregnant women (control group 33 cases) were compared. Results The levels of serum total cholesterol, triglyceride, low density lipoprotein and apolipoprotein B in ICP group were significantly higher than those in control group, while the levels of high density lipoprotein and apolipoprotein B in ICP group were significantly lower than those in control group (all P <0.05 ~ 0.01). Conclusion There is a clear abnormality in ICP maternal serum lipids and apolipoproteins.