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目的探讨抑癌基因PTEN在膀胱移行细胞癌中的表达及临床意义。方法采用PCR法观察40例膀胱移行细胞癌标本中PTEN的表达情况。结果40例膀胱移行细胞癌组织中9例(22.5%)PTEN表达阳性。随着肿瘤分期的进展PTEN的改变有增高的趋势但与肿瘤的分级无显著相关性。结论PTEN异常表达在膀胱移行细胞癌的进展中有重要作用,PTEN基因可作为评价膀胱移行细胞癌进展及预后的指标。
Objective To investigate the expression of tumor suppressor gene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods The expression of PTEN in 40 samples of bladder transitional cell carcinoma was observed by PCR. Results The expression of PTEN was positive in 9 cases (22.5%) of bladder transitional cell carcinoma tissues. With the progress of tumor staging, the change of PTEN has an increasing trend but has no significant correlation with the grade of tumor. Conclusions Abnormal expression of PTEN plays an important role in the progression of bladder transitional cell carcinoma. PTEN gene may be used as an index to evaluate the progress and prognosis of bladder transitional cell carcinoma.