Development of Self-Organized Polymeric Lewis Acid-Catalysts for the Zero-Emission Synthesis of 2-Am

• 作 者: J. Inanaga
• 机 构: Institute for Materials Chemistry and Engineering
• 出 处: 复旦学报（自然科学版）
• 发表日期: 2004年期
• 关键词: solid catalyst solvent-free reaction heterogeneous catalysis reusable catalyst

1Introductionβ-Amino alcohols are versatile synthetic intermediates for a wide range of biologically active natural and unnatural products. They can also serve as good chiral ligands for some asymmetric metal complex catalysts.The nucleophilic ring-opening of epoxides with an amine is one of the most efficient routes to obtain such β-amino alcohols with 1,2-trans stereochemistry. Therefore, various homogeneous catalysts have been developed for this transformation. Meanwhile, the development of efficient heterogeneous catalysts that can be easily prepared, recovered, and reused without losing their activities has currently received much attention from a practical and environmental point of view, and not a few such reusable heterogeneous catalysts (e. g., supported on inorganic materials or insoluble polymers) have been developed[1]. In general, however, they tend to show lower catalytic activities and selectivities compared to the corresponding homogeneous one, and the preparation of them are often tedious.