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TE-031是新研制的14元大环内酯类抗生素。为进一步评价其对耳鼻喉科感染症的效果,以角沙霉素(JM)为对照进行了双盲试验。99例急性扁桃腺炎患者,口服TE-011200mg,每日2次。102例急性扁桃腺炎患者给与JM400mg,每日3次,连续7日。研究委员会判定TE-031组有效率为87.4%,JM组为81.0%。主治医师判定TE-031组有效率为85.4%,JM组为87.3%。差别均无显著性意义。TE-031除菌率为100%,JM为95.6%。副作用,TE-031组为7/96(7.3%),JM组为10/91(11.0%),主要为消化道症状及皮疹。实验室检查,TE-031
TE-031 is a newly developed 14 yuan macrolide antibiotics. To further evaluate its effect on otorhinolaryngology, a double-blind trial was conducted using tamoxifen (JM) as a control. 99 cases of acute tonsillitis patients, oral TE-011200mg, 2 times a day. 102 cases of acute tonsillitis patients with JM400mg, 3 times a day for 7 days. The research board determined that the TE-031 group was 87.4% efficient, JM group was 81.0%. The attending physician determined that the TE-031 group had a response rate of 85.4% and the JM group had 87.3%. No significant difference was found. TE-031 sterilization rate of 100%, JM was 95.6%. Side effects were 7/96 (7.3%) in TE-031 group and 10/91 (11.0%) in JM group, mainly gastrointestinal symptoms and rashes. Laboratory examination, TE-031