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目的分析膀胱癌高表达基因BCA7与患者预后的关系。方法免疫组化方法检测BCA7蛋白在122例膀胱癌组织及32例配对癌旁组织中的表达水平,应用统计学方法分析BCA7表达水平与患者的临床病理特征及预后的相关性。结果 BCA7蛋白在膀胱癌组织中染色评分明显高于配对癌旁组织(P<0.001)。122例标本中,32例(26.2%)为BCA7低表达,90例(73.8%)为BCA7高表达。BCA7高表达与膀胱癌组织学分级、病理分期有关(P<0.05),与患者性别、年龄、肿瘤大小、肿瘤数量无关(P均>0.05)。BCA7低表达患者平均生存时间为(52.6±2.4)个月,高于BCA7高表达患者的(40.9±2.2)个月(P=0.003)。结论 BCA7蛋白在膀胱癌中高表达,其表达水平与患者预后相关,可能是一个较为理想的膀胱癌预后标志物。
Objective To analyze the relationship between BCA7 highly expressed in bladder cancer and the prognosis of patients. Methods Immunohistochemistry was used to detect the expression of BCA7 protein in 122 cases of bladder cancer and 32 cases of matched paracancerous tissues. The correlation between the expression of BCA7 and clinicopathological characteristics and prognosis was analyzed by statistical methods. Results The staining score of BCA7 protein in bladder cancer tissues was significantly higher than that in matched paracancerous tissues (P <0.001). Of the 122 specimens, 32 (26.2%) had low BCA7 expression and 90 (73.8%) had high BCA7 expression. The high expression of BCA7 was associated with the histological grade and pathological stage of bladder cancer (P <0.05), but not with the gender, age, tumor size and number of tumors (all P> 0.05). The mean survival time of BCA7 low expression patients was (52.6 ± 2.4) months, higher than that of BCA7 high expression patients (40.9 ± 2.2) months (P = 0.003). CONCLUSION: BCA7 protein is highly expressed in bladder cancer. The expression level of BCA7 is correlated with the prognosis of patients with bladder cancer. It may be a better prognostic marker of bladder cancer.