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目的 探讨血管紧张素转换酶(ACE)和肿瘤坏死因子α(TNF-α)基因多态性与结节病的相关性.方法 检索各数据库中截至2018年7月发表的评价ACE和TNF-α基因多态性与结节病关系的研究进行Meta分析.采用RevMan 5.3和Stata 12.0软件,进行隐性基因模型和显性基因模型分析,计算合并OR值及95％可信区间(95％ CI),并通过种族进行亚组分析和敏感性分析判断结果的稳定性.结果 共有28篇文献30项研究满足纳入标准,共7 888例纳入研究,其中结节病患者2 992例,健康对照4 896例.ACE I/D与结节病风险在两个模型中均无明显相关性(P＞0.05);TNF-α-308A/G与结节病风险显著相关(OR=1.34,95％ CI:1.13 ～1.58,P=0.0007),种族亚组分析结果显示在高加索人(OR=1.36,95％ CI:1.13 ～ 1.64,P=0.001)和亚洲人(OR=4.88,95％ CI:1.43 ～ 16.99,P=0.01)中均有统计学意义.结论 Meta分析发现,TNF-α-308位点AA/AG基因型与结节病易感性有关,携有AA/AG基因型者患结节病的风险增高,但未发现ACEL/D与结节病易感性之间存在显著的相关性.“,”Objective To evaluate the relationship between angiotensin converting enzyme (ACE) and tumor necrosis factors-α (TNF-α) gene polymorphism and sarcoidosis.Methods Meta analysis was carried out by retrieving the studies published up to July 2018 to evaluate the relationship between ACE and TNF-α gene polymorphism and sarcoidosis.RevMan 5.3 and Stata 12.0 software were used to analyze the combined OR value and 95％ confidence interval (95％ CI) by recessive model and dominant model.The stability of the results was judged by ethnic subgroup analysis and sensitivity analysis.Results A total of 28 articles and 30 studies met the inclusion criteria,including 7 888 cases,2 992 cases of sarcoidosis and 4 896 healthy controls.No significant association was found between ACE I/D and sarcoidosis using any model (P ＞ 0.05).TNF-α-308A/G was significantly associated with sarcoidosis risk (OR =1.34,95％ CI =1.13-1.58,P =0.0007).Ethnic subgroup analysis showed that the results were significantly different in both the Caucasians (OR =1.36,95％ CI =1.13-1.64,P =0.001) and the Asians (OR =4.88,95％ CI =1.43-16.99,P =0.01).Conclusions The meta-analysis identified that AA/AG genotypes at TNF-α-308 were associated with susceptibility to sarcoidosis.However,no significant correlation was found between ACE I/D and the susceptibility of sarcoidosis.