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目的分析万古霉素血药浓度监测结果及临床应用情况,为临床合理用药提供参考。方法采用反相-高效液相色谱法测定万古霉素血药浓度,对万古霉素血药浓度监测结果及相关用药信息进行比较分析。结果万古霉素谷浓度监测202次,平均血药谷浓度(14.36±8.12)mg/L,浓度小于10 mg/L的有68例次(33.66%),在10~20 mg/L的有100例次(49.51%),大于20 mg/L的有34例次(16.83%);肾功能正常与异常组间,血药谷浓度有显著性差异;用药前后,各项肾功能指标无显著性差异。结论万古霉素个体差异大,需加强血药浓度监测;针对肾功能异常患者,临床医生和药师需审慎评估给药剂量;临床医生应根据血药浓度及时调整用药方案,实现个体化给药。
Objective To analyze the monitoring results and clinical application of vancomycin plasma concentration in order to provide reference for clinical rational drug use. Methods The plasma concentration of vancomycin was determined by reversed-phase high-performance liquid chromatography (RP-HPLC). The monitoring results of vancomycin plasma concentration and the related medication information were compared. Results The vancomycin trough concentration was monitored 202 times with an average blood trough concentration of 14.36 ± 8.12 mg / L, 68 cases (33.66%) at concentrations less than 10 mg / L and 100 There were 34 cases (16.83%) of the cases with more than 20 mg / L in the cases (49.51%), and there was a significant difference in the concentration of the blood serum valley between the normal and abnormal renal groups difference. Conclusion Vancomycin has a large individual difference and needs to be monitored for plasma concentration. For patients with abnormal renal function, clinicians and pharmacists need to carefully evaluate the dosage. Clinicians should adjust the drug regimen in time to achieve individualized administration.