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Humanin(HN)是在阿尔茨海默病(Alzheimer’s disease,AD)患者大脑枕叶皮层未受损的脑区发现的一种由24个氨基酸组成的线性多肽,能有效抑制多种家族性阿尔茨海默病(familial Alzheimer’s disease,FAD)基因突变和β-淀粉样肽(β-amyloid peptide,Aβ)诱发的神经元凋亡,起初被认为是AD特异性的神经保护肽。然而近年来研究发现,humanin具有广谱的神经保护、细胞保护与抗炎作用,可改善胰岛素敏感性,延缓糖尿病的发生。Humanin在多种疾病模型中,如AD、2型糖尿病、动脉粥样硬化、心肌缺血、脑卒中等发挥保护作用,在以上疾病的防治中可能具有重要意义。
Humanin (HN), a 24-amino acid linear peptide found in the uninjured brain regions of the occipital cortex of patients with Alzheimer’s disease (AD), effectively inhibits multiple familial Alzheimer’s Mutations in the gene of familial Alzheimer’s disease (FAD) and neuronal apoptosis induced by β-amyloid peptide (Aβ) were originally thought to be AD-specific neuroprotective peptides. However, recent studies have found that humanin has a broad spectrum of neuroprotective, cytoprotective and anti-inflammatory effects that can improve insulin sensitivity and delay the onset of diabetes. Humanin plays a protective role in various disease models, such as AD, type 2 diabetes, atherosclerosis, myocardial ischemia, stroke and the like, and may play an important role in the prevention and treatment of these diseases.