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目的 观察热疗加介入治疗原发性肝癌的临床治疗效果。方法 自 1995年 8月～1998年 12月 ,采用BSD 2 0 0 0型热疗机 ,Sigma 6 0辐射器局部区域热疗联合介入治疗原发性肝癌2 0例。所有病例均为男性 ,平均年龄 49.2岁 ,肿瘤大小 6cm× 7cm× 8cm～ 13cm× 15cm× 17cm。采用高电阻铅测温针肿瘤内测温。每次热疗 40～ 6 0min ,2 0例共热疗 33次 ,75 %的病例热疗 1次 ,热疗达到的平均温度为 41.7℃ ,其中 2 5次 (75 .8% )热疗肿瘤内温度达 41℃以上。介入治疗采用动脉导管化疗加栓塞 ,先导管内注入PDD 80mg ,5 -FU 15 0 0mg ,EADM 5 0～ 6 0mg ,然后注入EADM10mg和碘油混合液进行栓塞。 结果 显效 6例占 30 % ,有效 7例占 35 %。中位生存期为 10个月。1年生存率为 35 % ,2年生存率为 10 %。全部病例均计算TEM 42 .5℃ ,TEM 42 .5℃≥ 2 0者 11例 ,2 0～ 10者 7例 ,<10者 2例。结论 采用BSD 2 0 0 0型热疗机和Sigma 6 0辐射器热疗是治疗原发性肝癌的有效手段 ,尤其是和介入治疗联合应用
Objective To observe the clinical effect of hyperthermia plus interventional treatment of primary liver cancer. Methods From Aug. 1995 to Dec. 1998, 20 cases of primary hepatocellular carcinoma (HCC) were treated with BSD200 type hyperthermia machine and Sigma 6 0 local area hyperthermia combined with interventional therapy. All cases were male, mean age 49.2 years old, tumor size 6cm × 7cm × 8cm ~ 13cm × 15cm × 17cm. Using high-resistance lead thermometer needle tumor temperature measurement. Each hyperthermia 40 ~ 60min, 20 cases of total hyperthermia 33 times, 75% of the cases of hyperthermia 1, hyperthermia reached an average temperature of 41.7 ℃, of which 25 (75.8%) hyperthermia tumors Within the temperature of 41 ℃ above. Interventional therapy with catheterized chemotherapy and embolization, PDD 80mg catheter, 5-FU 150mg, EADM 50 ~ 60mg, and then injected EADM10mg and lipiodol mixture for embolization. The results of 6 cases accounted for 30%, effective 7 cases accounted for 35%. The median survival was 10 months. The 1-year survival rate was 35% and the 2-year survival rate was 10%. All cases were calculated TEM 42 .5 ℃, TEM 42 .5 ℃ ≥ 2 0 in 11 cases, 20 to 10 in 7 cases, <10 in 2 cases. Conclusion BSD200 type thermotherapy machines and Sigma 60 radiators hyperthermia is an effective treatment of primary liver cancer, especially in combination with interventional therapy