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本文报导一男性15岁儿童,于14岁时发生小发作,脑电图示典型3次/秒棘—慢波,体重43.5公斤,给予丙戊酸钠1000毫克/天.用药后发作完全控制,脑电图亦正常.但治疗开始后二月,起先于上肢及大腿发生疼痛,几天后疼痛加重并扩散,变得苍白,疲乏,二月内体重下降4.5公斤,血沉为58毫米/小时,抗“0”为1250单位,给予阿斯匹林无效,症状加重,遂到作者处诊治,无阳性神经系体征发现,诉四肢疼痛,以致夜间不能入睡,除血沉为63毫米/小时,抗“0”960单位外,余实验室检查正常.x线检查大多数长骨的骨骺广泛密度增高(双侧桡骨,股骨和胫骨),远端尤为明显,疑为与药物有关的代谢改变所致.因此用乙琥胺代替丙戊酸钠,二周后
This article reports a male 15-year-old child who developed a minor episode at 14 years of age with a typical electroencephalogram of 3 spikes / second spike-slow wave weighing 43.5 kg giving sodium valproate 1000 mg daily, EEG was normal, but in February after the start of treatment, pain began to develop in the upper extremities and thighs. After a few days, the pain worsened and spread. It became pale and tired. Weight loss was 4.5 kg in February and ESR was 58 mm / Anti- “0 ” to 1250 units given aspirin invalid symptoms worsened, then went to the author for treatment, no positive neurological signs, v. Limb pain, so that night can not sleep, except for erythrocyte sedimentation rate of 63 mm / Laboratory tests were normal except for 960 units, with x-ray examinations of the extensive epiphyseal density of the long bones (bilateral radius, femur and tibia), especially at the distal end, and suspicion of drug-related metabolic changes Due to the replacement of sodium valproate with ethylsuccinate, two weeks later