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患者李××,男,67岁,退休工人。于83年11月1日上午因全身多发性红斑,水疱,痒一天来诊。患者因“慢支炎,肺气肿并感染”长期在本院内科门诊,用“庆大霉素,红霉素,氨茶硷,肌苷等治疗,均无不良反应。10月31日复诊,内科医生改用“复方庆大霉素”2毫升(含硫酸庆大霉素3万单位,TMP20毫克,天津生物化学制药厂生产)作肌注,每天二次。第一次注射后约两小时患者觉全身瘙痒,随后身体多处皮肤出现红斑、水疱,并逐渐增多,患者即自行停用所有药物及注射剂。次日上午来我科就诊。患者既往有多次磺胺药过敏史,表现为固定性药疹及多形红斑样皮疹。
Patient Lee × ×, male, 67 years old, retired worker. In the morning of November 1, 83 due to systemic multiple erythema, blisters, itch day visit. Patients with “chronic bronchitis, emphysema and infection” long-term in our hospital clinic, with “gentamicin, erythromycin, aminophylline, inosine and other treatment, no adverse reactions .On October 31th visit , Physicians switched to ”compound gentamicin" 2 ml (containing 30,000 units of gentamicin sulfate, TMP20 mg, Tianjin Biochemical Pharmaceutical Factory) for intramuscular injection twice a day after the first injection of about two Hours of patients with systemic itching, followed by multiple parts of the skin erythema, blisters, and gradually increased, the patient to disable all drugs and injections on the next morning to our department .Patients with multiple sulfa drug allergy history, manifested as Fixed drug eruptions and erythema multiforme-like rash.