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目的了解戊型肝炎病毒的变异。方法用双脱氧法对亚洲主要戊型肝炎流行国家的戊型肝炎病毒结构基因区段进行了分析，并根据ｃＤＮＡ序列确定了其氨基酸的序列。结果证明亚洲国家包括印度、缅甸、中国、巴基斯坦、吉尔吉斯坦流行的戊型肝炎病毒在基因水平和氨基酸水平上均有变化，核苷酸变化幅度在５％以内。氨基酸在测定的区域内未发现变异，与美洲发现的墨西哥株相比，亚洲株拟来自同一个祖先，基因和氨基酸水平的变化仅属基因漂移的范围。结论以亚洲戊型肝炎病毒基因为基础的疫苗将有广泛的保护作用
Objective To understand the variation of hepatitis E virus. Methods The HEV genomic regions of major HEV epidemics in Asia were analyzed by dideoxy method and their amino acid sequences were determined based on the cDNA sequence. The results showed that hepatitis E virus prevalence in Asian countries including India, Myanmar, China, Pakistan and Kyrgyzstan varied at the gene level and the amino acid level, and the nucleotide variation range was within 5%. No variation of amino acids was detected in the region tested. Compared with the Mexican strain found in America, the Asian strain is from the same ancestor. The changes of gene and amino acid level are only in the range of gene drift. Conclusion The hepatitis E virus-based vaccine will have a broad range of protection