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目的探讨医院真菌感染,分析病原菌及病因。方法采集近3年住院患者感染的深部标本进行真菌培养API鉴定,浓度梯度法抽样做白念珠菌的药敏试验及临床资料分析。结果3年共检出1225株真菌,2001—2003年检出率分别为24.2%、27.8%、48.0%。除念珠菌外还分离到隐球菌、马尔尼非青霉菌、组织胞浆菌等。两性霉素B耐药率仅3.3%,而氟康唑的耐药率3年分别为3.4%,8.3%,13.3%。结论真菌感染及其耐药率逐年上升,并与基础疾病及抗生素的使用有关。
Objective To investigate the hospital fungal infection and analyze the pathogens and etiology. Methods Inpatient infection in recent 3 years collected deep specimens for fungal culture API identification, concentration gradient sampling for Candida albicans susceptibility testing and clinical data analysis. Results A total of 1225 fungi were detected in 3 years. The detection rates were 24.2%, 27.8% and 48.0% respectively from 2001 to 2003. In addition to Candida albicans isolated, non-Penicillium marne, histoplasmosis and so on. The rate of amphotericin B resistance was only 3.3%, while that of fluconazole was 3.4%, 8.3% and 13.3% respectively in three years. Conclusions Fungal infections and their rates of resistance increase year by year and are related to the underlying diseases and the use of antibiotics.