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虽然缺血性心脏病(IHD)的急性病理生理机制还不清楚,但近来的研究表明症状性和无症状性心肌缺血、心肌梗塞及心脏猝死的发病率有昼夜变异性,在清晨最高,用β肾上腺素受体阻断剂治疗可以减少急性冠状动脉缺血的发生。由于血小板在稳定型冠状动脉心脏病症状转为不稳型的过程中起着重要作用,因此推测β阻断剂对 IHD 有益作用至少可能部分是由于降低血小板活性所致。本文就此进行了分析。在10名稳定型冠状动脉疾病的患者(男8女2,年龄为52～57岁)中进行随意的双(?)安壁剂对照交叉试验。患者随意分为2组,分别服用美多心安(200mg/次,2次/天)和安慰剂9天(第一阶段,随后9天(第二阶段)互相交换。每一时期患者均进行48h 非卧床心电图(AECG)跟
Although the acute pathophysiological mechanisms of ischemic heart disease (IHD) are unclear, recent studies have shown a diurnal variability in the incidence of symptomatic and asymptomatic myocardial ischemia, myocardial infarction and sudden cardiac death, with the highest in the early morning, Treatment with beta adrenergic blockade reduces the incidence of acute coronary ischemia. Since platelets play an important role in the stabilization of stable coronary heart disease symptoms, it is speculated that beneficial effects of beta blockers on IHD may be due, at least in part, to reduced platelet activity. This article has carried on the analysis to this. Randomized crossover trials of bis- (2-aminophenyl) -2,5-dimethylbenzamidone were performed in 10 patients with stable coronary artery disease (8 males and 2 females, aged 52-57 years). The patients were randomly divided into two groups, taking metoprolol (200mg / time, 2 times / day) and placebo for 9 days (the first phase, followed by 9 days (second phase) exchanged each other patients were 48h Ambulatory ECG (AECG) followed