论文部分内容阅读
目的 探讨 CD44 V 6表达与人胃癌生长方式、转移及预后的关系。方法 应用 S- P法 ,对 10 3例胃癌患者手术切除标本及 10例正常胃粘膜组织切片进行免疫组化染色 ,同时对其中 6 0例胃癌术后患者进行随访 ,随访期为 7～ 6 7个月。结果 (1) CD44 V 6在正常胃粘膜不表达 ,而胃癌中 6 0 .1%表达 ;(2 ) CD44 V6表达与 Borrm ann分型、周围淋巴结转移程度、TNM分期及脉管存在癌栓与否有关 (P<0 .0 5 ) ,而与组织学分级无关 (P>0 .0 5 ) ;(3)CD44 V6表达与生存率无明显关系 (P>0 .0 5 ) ;(4)伴有肝转移的胃癌细胞 CD44 V6呈强表达。结论 CD44 V6在胃癌中的表达对评估胃癌生长方式及转移有参考价值。
Objective To investigate the relationship between the expression of CD44 V 6 and the growth pattern, metastasis and prognosis of human gastric cancer. Methods S-P method was used to immunohistochemically stain 103 cases of gastric cancer and 10 cases of normal gastric mucosa. At the same time, 60 cases of gastric cancer patients were followed up for 7 ~ 67 Months. Results (1) CD44 V 6 was not expressed in normal gastric mucosa but 60.0% in gastric cancer. (2) The expression of CD44 V6 correlated with Borrm ann type, lymph node metastasis, TNM stage, (P <0.05), but no correlation with histological grade (P> 0.05); (3) There was no significant correlation between the expression of CD44 V6 and survival rate (P> 0.05); (4) CD44 V6 was strongly expressed in gastric cancer cells with liver metastasis. Conclusion The expression of CD44 V6 in gastric cancer has a reference value for evaluating the growth pattern and metastasis of gastric cancer.