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Metabotropic glutamate receptors (mGluR) aredensely expressed by striatal medium spiny neurons.Activation of mGluR in thes brain region alters localtransmitter release and behaviors of experimentalanimals. In particular, mGluR regulate transcriptionfactor and neuropeptide gene expression in striatalneurons through their connections with multipleintracellular effectors. This prominent involvement ofmGluR in overall cellular activity is pivotal for thedevelopment of neuronal plasticity underlying long-termadaptive changes in cellular physiolpgy related to a
Metabotropic glutamate receptors (mGluR) are desensitized by striatal medium spiny neurons. Activation of mGluR in the brain regions alters local transsemitter release and behaviors of experimentalanimals. In particular, mGluR regulate the transcription transcription factor and neuropeptide gene expression in striatal nerves through their connections with multiple intracellular effects. involvement of mGluR in overall cellular activity is pivotal for the development of neuronal plasticity underlying long-termadaptive changes in cellular physiolgy related to a