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目的观察婴儿巨细胞病毒性肝炎患者治疗前后CMV-PP65抗原的变化。方法共有84例患儿纳入研究,根据临床表现及CMV-IgM、CMV-PP65和肝功检查结果确诊后给予更昔洛韦抗病毒治疗,同时给予护肝、利胆、退黄等对症治疗,依据CMV-PP65转阴、肝功恢复等情况决定停用或减量使用更昔洛韦。结果治疗前后患儿的总胆红素(TB)、直接胆红素(DB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)含量差异均有统计学意义(P<0.05),治疗前CMV-IgM和CMV-PP65阳性率差异有统计学意义(P<0.05);治疗前后CMV-PP65阳性细胞数分别为(10.69±4.28)个/2×105白细胞和2.23±1.25个/2×105白细胞,差异有统计学意义(P<0.05)。结论在CMV肝炎诊断中,CMV-PP65抗原检测比CMV-IgM检测更灵敏,可供治疗时参考。
Objective To observe the changes of CMV-PP65 antigen in infants with cytomegalovirus hepatitis before and after treatment. Methods A total of 84 children were enrolled in the study. Antiviral treatment of ganciclovir was given according to clinical manifestations and results of CMV-IgM, CMV-PP65 and liver function test. At the same time, symptomatic treatment of hepatoprotective, gallbladder, According to CMV-PP65 negative, liver recovery and other circumstances decided to disable or reduce the use of ganciclovir. Results The levels of total bilirubin (TB), direct bilirubin (DB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in children before and after treatment were significantly different (P <0.05) (10.69 ± 4.28) / 2 × 105 leukocytes and 2.23 ± 1.25 cells / 2 × 105 leukocytes respectively before and after treatment (P <0.05), the positive rates of -IgM and CMV-PP65 were statistically different , The difference was statistically significant (P <0.05). Conclusion In the diagnosis of CMV hepatitis, CMV-PP65 antigen test is more sensitive than the CMV-IgM test for reference when treatment.