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目的:观察鼠神经生长因子联合α-硫辛酸治疗糖尿病周围神经病变的疗效。方法:162例患者随机分为治疗组与一般对照组,一般对照组和治疗组患者各81例,治疗组给予肌肉注射鼠神经生长因子联合静脉滴注α-硫辛酸来进行治疗,一般对照组仅给予α-硫辛酸治疗,观察其成效。结果:治疗组患者有效率80.49%,与一般对照组比较,具有显著性差异,具有统计学意义(P<0.05)。干预组术后炎症因子的表达与一般对照组比较,具有显著性差异,具有统计学意义(P<0.05);结论:鼠神经生长因子联合α-硫辛酸治疗糖尿病周围神经病变的疗效,值得临床推广应用。
Objective: To observe the therapeutic effect of rat nerve growth factor combined with α-lipoic acid on diabetic peripheral neuropathy. Methods: 162 patients were randomly divided into treatment group and general control group, the general control group and the treatment group of 81 patients, the treatment group were given intramuscular injection of nerve growth factor combined with intravenous infusion of α-lipoic acid for treatment, the general control group Only give α-lipoic acid treatment, observe its effectiveness. Results: The effective rate of the treatment group was 80.49%, which was significantly different from the control group (P <0.05). Compared with the control group, the expression of inflammatory cytokines in the intervention group had significant difference (P <0.05). Conclusion: The therapeutic effect of the combination of NGF and α-lipoic acid on diabetic peripheral neuropathy is worthy of clinical Promote the application.