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心房利钠因子(ANF)是近期发现的一种强有力的利尿、利钠和降低血压的肽类。ANF也可能参与肺功能的调节。ANF可以改善肺通气功能。因此,低动脉PO_2可以刺激ANF释放。作者观察到缺氧大鼠和离体兔心脏ANF释放增加。本文报道急性缺氧对ANF分泌是一种刺激因素。 材料和方法 本试验采用18只新西兰雄性白兔(体重2.2～3.2kg)。为保证急性缺氧引起的ANF分泌不受麻醉剂的干扰,7只兔给予α-氯醛糖(50mg/kg体重)和乌拉坦(400～800mg/kg体重)混
Atrial natriuretic factor (ANF) is a recently discovered potent diuretic, natriuretic and hypotensive peptide. ANF may also be involved in the regulation of lung function. ANF can improve lung ventilation. Therefore, low-arteries PO 2 can stimulate ANF release. The authors observed an increase in ANF release from hypoxia and isolated rabbit hearts. This paper reports that acute hypoxia is a stimulus for the secretion of ANF. Materials and Methods 18 New Zealand white rabbits (weighing 2.2 ~ 3.2kg) were used in this study. To ensure that ANF secretion caused by acute hypoxia was not disturbed by anesthetics, seven rabbits were given α-chloralose (50 mg / kg body weight) and urethane (400-800 mg / kg body weight) mixed