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为提高医用AZ91HP镁合金的耐蚀性和生物相容性,采用激光熔凝技术对镁合金进行熔凝处理。结果表明,AZ91HP镁合金熔凝层相组成为α-Mg和β-Mg17Al12,凝固组织为典型的树枝晶。模拟体液中腐蚀速率结果表明,熔凝层的耐蚀性较原始镁合金显著提高。在Hank’s中浸泡21 d后,可清楚看到一些絮状物沉积在熔凝层表面;能谱分析结果表明,絮状物中Ca,P比约为1.33,接近羟基磷灰石中Ca,P比(1.67)。原始镁合金的凝血酶原时间(PT)值为11.025 s,激光熔凝层的PT值为12.025 s,熔凝层具有较好的抗凝血性。细胞毒性实验结果表明,培养1 d后,在原始镁合金周围细胞出现破碎和固缩,极少数贴壁细胞。熔凝层表面则存在许多粘附细胞,熔凝层细胞死亡率较原始镁合金大有降低。
In order to improve the corrosion resistance and biocompatibility of medical AZ91HP magnesium alloy, laser melting technique was used to melt the magnesium alloy. The results show that the phase composition of AZ91HP magnesium alloy fusion layer is α-Mg and β-Mg17Al12, and the solidified structure is a typical dendrite. The simulated body fluid corrosion rate results show that the corrosion resistance of the fused layer is significantly higher than the original magnesium alloy. After soaking for 21 days in Hank’s, it was clear that some flocs deposited on the surface of the fused layer. The results of energy spectrum analysis showed that the ratio of Ca and P in the floc was about 1.33, close to Ca and P in hydroxyapatite Than (1.67). The prothrombin time (PT) value of the original magnesium alloy was 11.025 s, the PT value of the laser fused layer was 12.025 s, and the fused layer had better anticoagulant properties. The results of cytotoxicity test showed that after 1 day of culture, the cells around the original magnesium alloy were broken and constricted, a few adherent cells appeared. There were many adherent cells on the surface of the fused layer, and the cell death rate of the fused layer was much lower than that of the original magnesium alloy.