【摘 要】
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52例膀胱癌术后患者采用顺铂膀胱灌注疗法预防肿瘤复发.经12~24个月(平均21.6个月)随访,复发率为5.77%(3/52).14例发生不良副作用,其中膀胱刺激症4例,肉眼血尿及尿道狭窄各3例,骨髓抑制2例,发热及过敏样反应各1例.病
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52例膀胱癌术后患者采用顺铂膀胱灌注疗法预防肿瘤复发.经12~24个月(平均21.6个月)随访,复发率为5.77%(3/52).14例发生不良副作用,其中膀胱刺激症4例,肉眼血尿及尿道狭窄各3例,骨髓抑制2例,发热及过敏样反应各1例.病例选择及灌注方法与副作用发生有关.采用经导尿管膀胱灌注,充分溶解药物及严格掌握治疗指征可望预防和减少副作用发生.
Fifty-two patients with bladder cancer were treated with cisplatin bladder irrigation to prevent tumor recurrence. After 12 to 24 months (average 21.6 months) follow-up, the recurrence rate was 5.77% (3/52). Fourteen cases had adverse side effects, including 4 cases of bladder irritation, 3 cases of gross hematuria and urethral stricture, 2 cases of myelosuppression, and 1 case of febrile and allergic reactions. Case selection and perfusion methods and side effects occur. Bladder catheterization through the catheter, the full dissolution of drugs and strict indications of treatment is expected to prevent and reduce the incidence of side effects.
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