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目的:观察大剂量盐酸羟考酮治疗重度癌痛的疗效及不良反应。方法:选择口服常规剂量盐酸羟考酮镇痛效果不佳的重度癌痛住院患者30例,给予口服大剂量盐酸羟考酮(>150mg/d)治疗,根据疼痛缓解程度调整剂量,记录平均日剂量,评价镇痛效果及不良反应。结果:平均镇痛起效时间40min,镇痛持续9~16h,控制疼痛的剂量150~200mg/d。两周后完全缓解7例(23%),部分缓解22例(73),轻度缓解1例(5%)。结论:大剂量(150~200mg/d)盐酸羟考酮治疗重度癌痛仍然安全有效。
Objective: To observe the efficacy and side effects of high-dose oxycodone hydrochloride in the treatment of severe cancer pain. Methods: Thirty patients with severe cancer pain who received routine oral oxycodone hydrochloride analgesia were selected. Oral administration of oxycodone hydrochloride (> 150 mg / d) was given orally. The dose was adjusted according to the degree of pain relief and the average daily dose Dose, analgesic effect and adverse reactions. Results: The average analgesic onset time 40min, analgesic duration 9 ~ 16h, the dose of pain control 150 ~ 200mg / d. After two weeks, complete remission was achieved in 7 cases (23%), partial remission in 22 cases (73), and mild remission in 1 case (5%). Conclusions: High dose oxycodone hydrochloride (150-200 mg / d) is still safe and effective in the treatment of severe cancer pain.