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目的 探讨类风湿关节炎与HLA的相关性。方法 对51名汉族健康人和35例患者进行了HLA-DRB1*04基因分布调查。基因分型:自行设计合成引物,采用PCR-SSP方法测定基因型别。结果 汉族健康人HLA-DRB1*04携带者为23.5％,类风湿关节炎患者为51.4％,两组差别非常明显(P<0.001)。结论 汉族人群类风湿关节炎发病原因与遗传有密切关系,并证明携带HLA-DRB1*04基因的人患该病的危险性明显增加。
Objective To investigate the correlation between rheumatoid arthritis and HLA. Methods HLA-DRB1 * 04 gene distribution was investigated in 51 Han healthy people and 35 patients. Genotyping: self-designed synthetic primers, PCR-SSP method for genotyping. Results Han healthy people HLA-DRB1 * 04 carriers were 23.5%, rheumatoid arthritis patients was 51.4%, the difference between the two groups was very significant (P <0.001). Conclusion The incidence of rheumatoid arthritis in Han population is closely related to the genetic predisposition, and the risk of developing this disease is significantly increased in people with HLA-DRB1 * 04 gene.