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目前已在人体中证实有α、β两类防御素。尤其引人注目的是新近发现β－防御素在粘膜上皮广泛表达，其功能失活与病原微生物定植、集落于粘膜上皮而导致严重的粘膜感染关系密切。建立合适的动物模型以研究β－防御素在宿主粘膜屏障抵御病原微生物侵袭中的作用，意义重大。大鼠?
Has been confirmed in the human body α, β two defensins. Particularly noticeable is that β-defensin has recently been found to be widely expressed in the mucosal epithelium. Its inactivation is closely related to colonization of pathogenic microorganisms and colonization of the mucosal epithelium resulting in serious mucosal infections. It is of great significance to establish a suitable animal model to study the role of β-defensins in the resistance of the host mucosal barrier against pathogenic microorganisms. Rat?