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目的:探究中西医结合治疗对蛛网膜下腔出血患者围术期迟发性血管痉挛发生的影响。方法:选取2013年8月—2015年8月医院收治的80例蛛网膜下腔出血患者作为研究对象,根据入院时间先后将患者分成观察组和对照组各40例,对照组采用常规西药治疗,观察组采用中西医结合治疗,观察并记录两组患者入院后血浆神经肽Y含量和血管痉挛指数变化情况,记录6个月内并发症发生情况,分析比较。结果:两组患者血浆神经肽Y含量变化趋势一致,在入院第3天后升至最高水平,而在第7天时明显降低,且观察组显著低于对照组患者,两组比较有统计学意义(P<0.05)。两组患者入院第1 d时血管痉挛指数较高,两组比较无统计学意义(P>0.05);而10 d后均降低,且观察组患者血管痉挛指数显著低于对照组(P<0.05)。观察组患者6个月内迟发性血管痉挛发生概率为15.00%,对照组为35.00%,显著高于观察组患者,且观察组二次出血和脑出血人数均较少,两组比较有统计学意义(P<0.05)。结论:中西医结合治疗围手术期蛛网膜下腔出血患者临床疗效好,发生迟发性血管痉挛等并发症的概率较低,有利于预后,提高患者生活质量,值得广泛推荐使用于临床当中。
Objective: To investigate the effect of integrated traditional Chinese and western medicine on the occurrence of delayed vasospasm in patients with subarachnoid hemorrhage during perioperative period. Methods: Eighty patients with subarachnoid hemorrhage admitted from August 2013 to August 2015 in our hospital were enrolled. According to the time of admission, the patients were divided into observation group and control group, 40 cases each. The control group was treated with routine western medicine, The observation group was treated with integrated traditional Chinese and western medicine. The changes of plasma neuropeptide Y and vasospasm index in both groups were observed and recorded after the admission. The incidence of complications within 6 months were recorded and compared. Results: The changes of plasma neuropeptide Y in both groups showed the same trend, which reached the highest level on the 3rd day after admission and decreased significantly on the 7th day, and the observation group was significantly lower than that of the control group P <0.05). The index of vasospasm was higher on the first day of admission in both groups, with no significant difference between the two groups (P> 0.05) and decreased after 10 days, and the vasospasm index in the observation group was significantly lower than that in the control group (P <0.05 ). The incidence of delayed vasospasm in observation group was 15.00% in 6 months and 35.00% in control group, which was significantly higher than that in observation group, and the number of secondary bleeding and cerebral hemorrhage in observation group was less than that in observation group Significance (P <0.05). Conclusion: The combination of traditional Chinese and Western medicine in the treatment of perioperative patients with subarachnoid hemorrhage clinical efficacy is good, the incidence of complications such as delayed vasospasm lower probability is beneficial to the prognosis and improve the quality of life of patients, it is widely recommended for clinical use.