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目的探讨胃食管反流病(GERD)以呼吸道症状为临床表现的诊治情况及发病机制。方法以呼吸道症状为临床表现的胃食管反流病患者40例,行胃镜检查和(或)24 h食管p H监测、质子泵抑制剂(PPI)试验等治疗,观察治疗效果。结果确诊的40例患者经给予PPI及促动力药物、胃黏膜保护剂治疗4~6周后25例临床症状基本消失,所有患者经胃镜复查,食管炎症消失,黏膜恢复正常,其余病例继续巩固治疗2周后全部临床治愈。结论胃食管反流病由于其临床表现的多样化,部分患者消化道症状较轻或缺如,而以呼吸道症状为主,临床易误诊或漏诊,呼吸科医师应加强对胃食管反流病临床表现及发病机制的认识,以减少误诊、漏诊。
Objective To investigate the diagnosis and treatment of gastroesophageal reflux disease (GERD) with respiratory symptoms and its pathogenesis. Methods Forty patients with gastroesophageal reflux disease with respiratory symptoms were enrolled. Gastroscopy and / or 24 h esophageal p H monitoring and proton pump inhibitor (PPI) test were performed to observe the therapeutic effect. The results of the diagnosis of 40 patients given PPI and motility drugs, gastric mucosal protective agent 4 to 6 weeks after the clinical symptoms disappeared 25 cases, all patients underwent endoscopy, esophageal inflammation disappeared, the mucosa returned to normal, and the remaining cases continue to consolidate the treatment After 2 weeks all the clinical cure. Conclusion Gastroesophageal reflux disease due to the diversification of clinical manifestations, some patients with mild or mild gastrointestinal symptoms, and mainly respiratory symptoms, clinical misdiagnosis or missed diagnosis, respiratory physicians should strengthen the clinical treatment of gastroesophageal reflux disease Performance and pathogenesis awareness, to reduce misdiagnosis, missed diagnosis.