论文部分内容阅读
目的 :观察静脉注射丙种球蛋白 ( IVIG)治疗毛细支气管炎后肿瘤坏死因子 ( TNF-α)水平变化及其对哮喘发病机理的影响。方法 :40例确诊为呼吸道合胞病毒 ( RSV)感染所致毛细支气管炎患儿随机分为观察组和对照组 ,观察组治疗上加用 IVIG,采用双抗体夹心酶联免疫法检测TNF- α水平。对比两组病人血清 TNF- α的变化。结果 :1治疗前患儿 TNF- α较正常小儿对照组明显升高 ;2常规治疗 + IVIG治疗的观察组较对照组同期 TNF- α水平恢复快 ,病情好转快。结论 :IVIG可以抑制 TNF- α的过多产生 ,对毛细支气管炎引发哮喘的发生、发展可以起到一定的控制作用
Objective: To observe the changes of tumor necrosis factor (TNF-α) and its effect on the pathogenesis of asthma after intravenous injection of gamma globulin (IVIG) for bronchiolitis. Methods: Forty patients with bronchiolitis caused by respiratory syncytial virus (RSV) infection were randomly divided into observation group and control group. IVIG was used in the observation group, and TNF-α was detected by double antibody sandwich enzyme-linked immunosorbent assay Level. The changes of serum TNF-α in two groups were compared. Results: 1 The levels of TNF-α in children before treatment were significantly higher than those in normal children. The levels of TNF-α in the two groups treated with conventional therapy and IVIG were recovered faster than those in the control group. Conclusion: IVIG can inhibit the excessive production of TNF-α, which may play a role in controlling the occurrence and development of bronchitis-induced asthma