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抗旱孕药物的研究对计划生育具有重要意义。Jean G T等合成了系列11-β取代19去甲基孕激素类化合物,发现11β-[4-(N,N—二甲氨基)苯基]-17α-(丙炔-1)-Δ~(4,9)-雌甾二烯-17β-羟-3-酮具有抗旱孕的活性(简称RU-486)。它是一种结构新型的抗早孕药,具有终止娠妊的作用。药理学研究表明RU-486与孕激素受体有较强的亲和力,能阻
Research on drought-resistant drugs is of great significance to family planning. A series of 11-β substituted 19-methyl progestin compounds were synthesized by Jean GT et al., And 11β- [4- (N, N-dimethylamino) phenyl] -17α- (propyne- 4,9) -estradiol-17β-hydroxy-3-keto has anti-drought activity (RU-486). It is a new type of anti-early pregnancy pills, with the role of termination of pregnancy and pregnancy. Pharmacological studies have shown that RU-486 and progesterone receptors have a strong affinity, can block