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Abl相互作用蛋白-1(Abl interactor protein 1,Abi1)作为接合蛋白参与肌动蛋白重建,在细胞的多种生物学行为中发挥重要的作用;通过形成不同的大分子复合物,调控着多种与肿瘤细胞增殖、凋亡、黏附、迁移等相关的信号传导通路;并与某些类型的白血病及部分恶性实体肿瘤的发生发展密切相关。Abi1作为潜在的分子靶点在肿瘤的基础和临床研究中显示出广阔的研究前景。
Abl interacting protein-1 (Abi1), as a junction protein involved in actin rebuilding, plays an important role in various biological behaviors of cells. By forming different macromolecular complexes, Abi interacts with many kinds of macrophages And cell proliferation, apoptosis, adhesion, migration and other related signal transduction pathway; and some types of leukemia and some malignant solid tumors are closely related to the occurrence and development. Abi1 as a potential molecular target in the basic and clinical research of tumors has shown broad research prospects.