论文部分内容阅读
目的：观察延髓腹外侧头端（ＲＶＬＭ）注射莫索尼定（Ｍｏｘ）对麻醉大鼠血压（ＢＰ）、心率（ＨＲ）及肾交感神经放电（ＲＳＮＡ）的影响．方法：麻醉大鼠ＲＶＬＭ注射１μＬＭｏｘ１，１０，１００μｍｏｌ·Ｌ－１，同步记录ＢＰ，ＨＲ及ＲＳＮＡ．结果：Ｍｏｘ１，１０，１００μｍｏｌ·Ｌ－１分别使ＢＰ从１３９±１０ｋＰａ降至１３０±１７ｋＰａ（Ｐ＜００５），１３８±１８ｋＰａ至１１４±１５ｋＰａ（Ｐ＜００１），ａｎｄ１３９±１９ｋＰａ至９４±１７ｋＰａ（Ｐ＜００１）．Ｍｏｘ不影响ＨＲ．Ｍｏｘ１μｍｏｌ·Ｌ－１增加ＲＳＮＡ５０％（Ｐ＜００５），１０μｍｏｌ·Ｌ－１对ＲＳＮＡ无影响（Ｐ＞００５），１００μｍｏｌ·Ｌ－１则降低ＲＳＮＡ２３％（Ｐ＜００５）．在缓冲神经切断大鼠，Ｍｏｘ１０μｍｏｌ·Ｌ－１抑制ＲＳＮＡ５０％（Ｐ＜００５），明显不同于缓冲神经完整的动物（Ｐ＜００１）．结论：麻醉大鼠ＲＶＬＭ注射Ｍｏｘ可降低ＢＰ，但不影响ＨＲ，且ＲＳＮＡ变化与其降压作用并不平行
Objective: To observe the effect of moxonidine (Mox) injected into rostral ventrolateral medulla (RVLM) on blood pressure (BP), heart rate (HR) and renal sympathetic nerve discharge (RSNA) in anesthetized rats. Methods: 1μL of Mox1, 10, 100μmol·L-1 was injected into the RVLM of anesthetized rats, BP, HR and RSNA were recorded simultaneously. Results: Mox1, 10, 100μmol·L-1 decreased BP from 139 ± 10kPa to 130 ± 17kPa (P <005), 138 ± 18kPa to 114 ± 15kPa (P <001), and139 ± 19kPa to 94 ± 17kPa (P <001). Mox does not affect HR. Mox1μmol·L-1 increased RSNA50% (P <005), while10μmol·L-1 had no effect on RSNA (P> 0.05), while100μmol·L-1 reduced RSNA23% (P <005). MNCs inhibited RSNA by 50% (P <005), which was significantly different from that in intact animals (P <001). CONCLUSIONS: Injection of Mox in the RVLM of anesthetized rats decreases BP but does not affect HR, and changes in RSNA are not parallel to its antihypertensive effect