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目的总结和分析阿司匹林联合奥扎格雷钠治疗短暂性脑缺血发作的安全性和疗效。方法将本院2009年1月至2011年1月收入院的70例TIA患者随机分成两组,对照组34例,给予肠溶阿司匹林口服,治疗组36例,给予阿司匹林及奥扎格雷钠联合治疗,均持续1个月。结果随访3个月,对照组34例TIA发作患者中19例在10d内完全控制,有效率55.9%(19/34),5例无效,无效率14.7%(5/34),发展为脑梗死10例。治疗组36例T1A发作患者中35例在10d内完全控制无复发,有效率97.2%(35/36),1例无效,无效率2.8%(1/36),无出血并发症,无1例发展为脑梗死。两组有效率比较差异有统计学意义(P<0.05)。结论阿司匹林联合奥扎格雷钠治疗治疗TIA安全有效,无明显不良反应,不易复发。
Objective To summarize and analyze the safety and efficacy of aspirin combined with ozagrel sodium in the treatment of transient ischemic attack. Methods Seventy patients with TIA admitted to our hospital from January 2009 to January 2011 were randomly divided into two groups. The control group consisted of 34 patients who were given oral aspirin orally. The treatment group was given 36 patients with aspirin and ozagrel sodium , All lasting 1 month. Results All the patients were followed up for 3 months. Twenty-four of the 34 TIA patients in the control group were completely controlled within 10 days. The effective rate was 55.9% (19/34), 5 were ineffective, and 14.7% (5/34) ineffective. The patients developed cerebral infarction 10 cases. Among the 36 patients with T1A attack in the treatment group, 35 patients achieved complete control within 10 days with no recurrence, the effective rate was 97.2% (35/36), one was ineffective and the inefficiency rate was 2.8% (1/36) Development of cerebral infarction. The difference between the two groups was statistically significant (P <0.05). Conclusion Aspirin and ozagrel sodium treatment of TIA safe and effective, no obvious adverse reactions, not easy to relapse.