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应用微波-SP免疫组化法对95例胃癌，60例癌分粘膜和60例正常粘膜组织进行了细胞粘附分子CD15表达研究。结果，CD15在胃癌中呈增强表达，阳性率（86．3％）显著高于非癌粘膜组织（P＜0．05）。CD15在本分化型胃癌的“”表达强度显著高于高分化型胃癌（P＜0．005）。CD15表达阳性率在胃癌浸润至肌层和浆膜层者显著高于浸润至粘膜层及粘膜下层考（P＜0．025），淋巴结转移阳性组显著高于阴性组（P＜0．005）。提示，CD15对判断胃癌的分化水平、恶性程度、浸润转移和预测预后有一定临床意义。
Microwave-SP immunohistochemistry was used to study the expression of cell adhesion molecule CD15 in 95 cases of gastric cancer, 60 cases of cancerous mucosa and 60 cases of normal mucosa. As a result, CD15 showed enhanced expression in gastric cancer, and the positive rate (86.3%) was significantly higher than that of non-cancerous mucosa (P<0.05). The expression intensity of CD15 in this differentiated gastric cancer was significantly higher than that of highly differentiated gastric cancer (P<0.005). The positive rate of CD15 expression was significantly higher in gastric cancer infiltrating into muscular layer and serosal layer than infiltration into mucosal layer and submucosa (P<0.025). The positive rate of lymph node metastasis was significantly higher than that of negative group (P<0.005). . It is suggested that CD15 has certain clinical significance for judging the differentiation of gastric cancer, malignancy, invasion and metastasis, and predicting prognosis.