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探讨高原藏族酒精性肝病患者肝脏病变的超微病理学改变及其发生机制 ;方法 :经临床确定的 2 0例酒精性肝病患者肝穿标本电镜观察 ;结果 :①肝细胞主要为大泡性脂变 ,肝细胞坏死灶形成伴中性粒细胞浸润 ;②窦周隙贮脂细胞活化形成胶原纤维、肝细胞间纤维化致星芒状和条索状纤维间隔形成 ;③肝细胞内滑面内质网增生 ,偶见巨大线粒体 ;结论 :洒精性肝病纤维化形成的主要细胞是贮脂细胞 ,其次是肝细胞 ,一旦纤维化形成发展致肝硬变 ,很难恢复。
To investigate the ultrastructural pathological changes of liver lesions in patients with alcoholic liver disease in Tibetan plateau and its mechanism.Methods: Twenty-five cases of alcoholic liver disease were identified by electron microscopy. Results: ① The hepatocytes were mainly vesicular lipid Necrosis of liver cells formed with neutrophil infiltration; ② sinusoidal crevice fat cells activated to form collagen fibers, interstitial fibrosis of hepatic stellate and cord-like fibers to form intervals; ③ intrasynaptic Cytoplasm hyperplasia, occasionally huge mitochondria; Conclusion: Azoospermia liver fibrosis formation of the main cells are fat storage cells, followed by the liver cells, once the formation of fibrosis development and development of cirrhosis, it is difficult to recover.