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目的：探讨不同剂量阿托伐他汀治疗冠心病患者颈动脉斑块的疗效和安全性。方法：选择我院2013年4月至2015年1月心内科门诊及住院的冠心病合并颈动脉斑块的患者84例，随机分为观察组与对照组各42例。观察组患者接受高剂量（40mg/d）阿托伐他汀治疗，而对照组患者接受低剂量（10m g/d）阿托伐他汀治疗，共治疗6个月。对两组患者的总体血脂水平、颈动脉内—中膜厚度（IMT）、斑块厚度等指标及药物的安全性进行比较观察。结果：治疗后，察组患者TG、TC、LDL-C等指标下降显著低于对照组， IMT 水平、斑块厚度改善、HDL-C水平升高优于对照组。差异有统计学意义(P＜0.05)。结论：采用高剂量阿托伐他汀治疗冠心病合并颈动脉斑块患者，疗效显著，安全性高，临床上值得继续推广。“,”Objective To study the different dose atorvastatin treatment efficacy and safety of carotid plaques in patients with coronary heart disease.Methods Our hospital between April 2013 and January 2013 cardiology outpatient and hospitalization of patients with coronary heart disease combined carotid plaques in 84 cases, were randomly divided into observation group and control group (n =42). Observation group patients received high dose (40 mg/d) atorvastatin treatment, while control group patients received low dose (10 mg/d) atorvastatin treatment, a total of 6 months. Overall lipid levels of two groups of patients, the carotid artery - such as the thickness of film thickness (IMT), plaque index and the safety of the drug comparative observation.Results After treatment, was made in the group of patients with TG, TC, LDL - C index decreased significantly lower than the control group, improve the level of IMT, plaque thickness, elevated levels of HDL - C is better than the control group. The difference was statistically significant (P< 0. 05).Conclusion Using high dose atorvastatin treatment of patients with coronary heart disease (CHD) with carotid plaques, the curative effect is distinct, high safety, clinical worth to promote.