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Free tissue autograft is an effective means to repairmajor soft tissue defects of extremities. Emergentflap coverage by microsurgery will curtail theduration of the treatment and facilitate early functionrecovery. 1,2 However, trauma could inducehypercoagulability which could be fatal to emergent freeflap transplantation.3-8 To correlate the severity oftrauma and the tendency to hypercoagulability, wechose the patients who suffered from open injuries tothe extremities, including those who needed emergencyreconstruction with microsurgery, and studied the serialchanges in coagulation and anti-coagulation system atdifferent posttraumatic stages.