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Objective: To study the changes in 5α-reductase type Ⅱactivity in sex glands of pubertal and adult male rats with diabetes. Methods: Pubertal (40 days old) and adult (90 days old) male Wistar rats were used, 30 animals in each group. Each group was randomly divided into 3 subgroups: the control (C), the diabetic (D) and the diabetic with insulin replacement (ID). The activity of 5α-reductase type Ⅱ was determined with thin layer chromatography in the epididymis, prostate and testis. Results: (1) In all the sex glands of pubertal rats, the enzyme activity was significantly lower in group D than in groups C and ID. (2) In all the sex glands of adult rats, there was no significant difference in the activity. Conclusion: In male rats, the activity of 5αa-reductase type Ⅱ in sex glands is more vulnerable to diabetes in pubertal rats than in adult rats.
Objective: To study the changes in 5α-reductase type Ⅱ activity in sex glands of pubertal and adult male rats with diabetes. Methods: Pubertal (40 days old) and adult (90 days old) male Wistar rats were used, 30 animals in each group The activity of 5α-reductase type Ⅱ was determined with thin layer chromatography in the epididymis, prostate (C), the diabetic (D) and the diabetic with insulin replacement (ID) and the testis. (1) In all the sex glands of pubertal rats, the enzyme activity was significantly lower in group D than in groups C and ID. (2) In all the sex glands of adult rats, there was no significant difference in the activity. Conclusion: In male rats, the activity of 5αa-reductase type Ⅱ in sex glands is more vulnerable to diabetes in pubertal rats than in adult adults.