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血管平滑肌的异常收缩是引起许多疾病的重要因素,如高血压,脑血管痉挛等,对于平滑肌收缩调节机制的研究为治疗这些疾病带来新的思路和方向。研究表明小GTP结合蛋白RhoA及其下游信号分子ROCK在平滑肌收缩调节,尤其是钙敏化调节机制中起到关键作用。RhoA/ROCK通路通过抑制MLCP活性而增强MLC的磷酸化水平,从而调节平滑肌收缩,此外,它还参与调节其它细胞的多种细胞功能,如应力纤维的生成,细胞分裂及迁移等。本综述主要介绍RhoA/ROCK通路在血管平滑肌收缩功能的调节机制及研究进展。
Abnormal contraction of vascular smooth muscle is caused by many diseases, such as high blood pressure, cerebral vasospasm, etc., for the study of smooth muscle contraction regulation mechanism for the treatment of these diseases bring new ideas and directions. Studies have shown that the small GTP-binding protein RhoA and its downstream signaling molecule ROCK play a key role in the regulation of smooth muscle contraction, especially the mechanism of calcium sensitization. The RhoA / ROCK pathway regulates smooth muscle contraction by increasing the phosphorylation of MLC by inhibiting MLCP activity. In addition, it is involved in the regulation of various cellular functions of other cells, such as generation of stress fibers, cell division and migration. This review mainly introduces the regulatory mechanism of RhoA / ROCK pathway in vascular smooth muscle contraction and its research progress.