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The medium effect of nucleon-nucleon cross section σmedNN(αm) on the isoscaling parameter α is investigated for two central nuclear reactions 40 Ca+40 Ca, 60 Ca+6o Ca within isospin-dependent quantum molecular dynamics at beam energies from 40 to 50 MeV/nucleon. It is found that there is the very obvious medium effects of nucleonnucleon cross section σmedNN(αm) on the isoscaling parameters α. In this case the isoscaling parameter α is a possible probe of the medium effect of nucleon-nucleon cross section σmedNN(αm) in the heavy ion collisions. The mechanism of the above-mentioned properties is studied and discussed.