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目的:探讨茵栀黄口服液对雌激素诱导的妊娠期大鼠肝内胆汁淤积的影响。方法:将妊娠12 d的SD大鼠随机分为正常对照组、模型对照组、阳性对照组和茵栀黄口服液高、中、低剂量组。肌内注射苯甲酸雌二醇(EB),1 h后灌胃给药,1周后测定妊娠大鼠胆汁流量和血清总胆汁酸(TBA)、总胆红素(TBIL)、碱性磷酸酶(AKP)、雌激素(E2)水平。结果:茵栀黄口服液可以增加EB诱导的肝内胆汁淤积妊娠大鼠的胆汁流量,显著降低血清中TBA、TBIL、AKP和E2水平。结论:茵栀黄口服液可以改善EB诱导的妊娠期大鼠肝内胆汁淤积状况,其作用可能是通过降低大鼠体内的雌激素水平而产生。
Objective: To investigate the effect of Yinzhihuang Oral Liquid on estrogen-induced intrahepatic cholestasis in rats. Methods: SD rats of 12 d of gestation were randomly divided into normal control group, model control group, positive control group and Yinzhihuang oral liquid high, medium and low dose groups. After 1 h, intraperitoneal injection of estradiol benzoate (EB) was given. After 1 week, the bile flow rate, total bile acid (TBA), total bilirubin (TBIL), alkaline phosphatase (AKP), estrogen (E2) levels. Results: Yinzhihuang Oral Liquid can increase bile flow in EB induced pregnant rats with intrahepatic cholestasis and significantly decrease the levels of TBA, TBIL, AKP and E2 in serum. Conclusion: Yinzhihuang Oral Liquid can improve the intrahepatic cholestasis induced by EB in pregnant rats, which may be caused by the decrease of estrogen level in rats.