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Pulmonary alveolar proteinosis (PAP) is an uncommondisease first reported by Rosen et al in 1958, andcharacterized by the accumulation of surfactant proteinsand phospholipids within the alveolar spaces. AcquiredPAP is divided into two forms based on clinical features:idiopathic PAP and secondary PAP. Secondary PAP isreported to be associated with haematologicalmalignancies, Pneumocystis carinii pneumonia andinhalation of silica or titanium, and the most frequentunderlying disease of secondary PAP is haematologicalmalignancy. The exact incidence of PAP inhaematological malignancies is still obscure, since therehave been only sporadic reports of secondary PAP.
Pulmonary alveolar proteinosis (PAP) is an uncommondisease first reported by Rosen et al in 1958 and is characterized by the accumulation of surfactant proteins and phospholipids within the alveolar spaces. AcquiredPAP is divided into two forms based on clinical features: idiopathic PAP and secondary PAP. Secondary PAP isreported to be associated with haematological malignancies, Pneumocystis carinii pneumonia and inhalation of silica or titanium, and the most frequentunderlying disease of secondary PAP is haematological malignancy. The exact incidence of PAP inhaematological malignancies is still obscure, since therehave been only sporadic reports of secondary PAP.