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目的 探讨 Ａ ｌｚｈｅｉｍ ｅｒ 病（ Ａ Ｄ）与铝的关系以及中药对 Ａ Ｄ 的治疗作用。方法 实验采用氯化铝（ Ａ ｌ Ｃｌ３ ）制作小鼠拟痴呆模型，研究中药开心散对小鼠学习记忆和超氧化物歧化酶与脂质过氧化物（ Ｓ Ｏ Ｄ／ Ｍ Ｄ Ａ ）活性及脑组织蛋白含量的影响。结果 Ａ ｌ Ｃｌ３ 中毒小鼠记忆能力明显降低，表现为在电、水迷宫中准确次数减少，准确率降低。血清、肝、心、脑组织 Ｓ Ｏ Ｄ 活性下降；心、肝组织 Ｍ Ｄ Ａ 含量升高；脑组织蛋白含量降低。模型鼠服用开心散后，记忆能力明显提高， Ｓ Ｏ Ｄ 活性升高， Ｍ Ｄ Ａ 降低，脑组织蛋白含量升高。结论 开心散具有明显益智健脑、防衰老、增强记忆功能。
Objective To investigate the relationship between A lzheimer disease (A D) and aluminum and the therapeutic effect of Chinese medicine on A D. Methods A mouse model of dementia was made using aluminum chloride (AlCl3) to study the effects of Chinese medicine Kaixinsan on learning and memory, superoxide dismutase and lipid peroxide (S O D / M D A ) activity in mice. The effect of protein content in brain tissue. Results The memory capacity of A1Cl3 poisoned mice was significantly decreased, showing a decrease in accuracy and accuracy in the electric and water maze. The activity of SOD decreased in serum, liver, heart and brain; the content of MDA in heart and liver increased; the protein content in brain decreased. After the model rats took Kaixinsan, their memory ability increased significantly, their S O D activity increased, M D A decreased, and brain tissue protein content increased. Conclusion Kaixinsan has obvious functions of brain-feeding, anti-aging and memory enhancement.