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目的: 调查贵州省三都水族葡萄糖-6 -磷酸脱氢酶(glucose-6 -phosphatedehydrogenase,G6PD)缺乏症的基因频率。方法:随机选取589名三都县当地水族男性居民,先用硝基四氮唑蓝纸片法进行筛查,再用G6PD/6PGD定量法验证。结果: 589名三都县水族男性居民中检出G6PD缺乏症68例,G6PD缺乏症的基因频率为0. 115 4。结论:贵州省三都水族居民G6PD缺乏症有着很高的基因频率,此次调查为了解贵州省少数民族G6PD缺乏症的分布特征以及当地水族居民G6PD缺乏症的防治提供了理论依据。
Objective: To investigate the gene frequency of G6PD deficiency in Sandu Shui, Guizhou Province. Methods: A total of 589 male local aquaria were selected from Sandu County. The samples were screened by the method of nitrotetrazolium blue and then quantified by G6PD / 6PGD. Results: Sixty-eight cases of G6PD deficiency were detected in 589 male residents in Sanduo County, and the frequency of G6PD deficiency was 0. 115 4. Conclusion: G6PD deficiency in Sanda residents in Guizhou Province has a high genetic frequency. This survey provides a theoretical basis for understanding the distribution characteristics of G6PD deficiency in Guizhou ethnic minority and the prevention and treatment of G6PD deficiency among local aquatic residents.