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抗菌药物热是指因药物的化学结构及患者的特异体质 ,在用药过程中表现出来的个体特异性的发热反应。其发病机制可能与变态反应有关 ,以Ⅲ型变态反应最多见。临床上主要表现为用药后立即或用药后 7～ 1 4d出现的无法用当前病症解释的低热至中等热 ,可伴有皮疹、肝、脾、淋巴结肿大、全身不适等。主要诊断依据是 :用药后体温上升 ;停药后体温复常 ;无明确的感染证据。处理原则 :在排除感染的基础上 ,停药观察 ;感染尚未控制者 ,更换致热可能性较小的抗菌药物 ,并简化治疗 ;或合并使用小剂量糖皮质激素
Antimicrobial drug fever is due to the chemical structure of the drug and the patient’s specific physique, in the course of medication showed that the individual-specific fever response. Its pathogenesis may be related to allergic reactions, the most common type Ⅲ allergic reaction. The main clinical manifestations of medication immediately after or 7 ~ 14d after the emergence of the current illness can not explain the low fever to moderate fever, accompanied by rash, liver, spleen, lymph nodes, general malaise and so on. The main diagnosis is based on: the body temperature rose after treatment; body temperature after stopping normal; no clear evidence of infection. Treatment principle: In the exclusion of infection based on the withdrawal observed; infection has not been controlled, the replacement of fever less likely to antibiotics, and to simplify the treatment; or combination of low-dose glucocorticoid