论文部分内容阅读
选7例糖尿病患者,经ECT检查证实均有胃排空障碍;糖尿病组及对照组均行OGTT试验,且在服糖的0、30、60、120、180分钟各取血经放免法测血浆内SS及MOT。结果:糖尿病组空腹SS水平明显低于对照组(9.3±3.7)ng/L,(17.4±7.5)ng/L,而服糖后糖尿病组的SS水平比对照组增高(92.4±41)ng/L,(70±28.2)ng/L,且高峰持续时间较长;糖尿病组空腹MOT水平与对照组相比无显著差异(88.3±38.7)ng/L,(94.4±38.2)ng/L,而服糖后糖尿病组MOT水平较对照组增高,对照组服糖后MOT水平较自身空腹水平降低。结果表明迷走神经受损后,SS分泌降低,而服糖后糖尿病组的SS升高既抑制了胰岛素的释放,又影响了胃肠道的肽能神经纤维。糖尿病患者服糖后血浆中胃动素的升高可能是由于胃肠道运动功能的降低诱发了胃动素的释放。
Eleven patients with diabetes mellitus were confirmed by ECT. Gastric emptying was confirmed in both diabetic and control groups. OGTT test was performed in both diabetic and control groups, and blood was collected by radioimmunoassay at 0, 30, 60, 120, Within the SS and MOT. Results: The level of SS in diabetic group was significantly lower than that in control group (9.3 ± 3.7) ng / L, (17.4 ± 7.5) ng / L, while SS level in diabetic group was 92.4 ± 41 ng / L, (70 ± 28.2) ng / L, and the duration of the peak was longer. There was no significant difference in fasting MOT level between the diabetic group and the control group (88.3 ± 38.7 ng / L, 94.4 ± 38.2 ng / L, The level of MOT in patients with diabetes mellitus was higher than that in the control group, and the level of MOT in the control group was lower than that in the control group. The results showed that after vagal nerve damage, SS secretion decreased, but the elevated SS in the diabetic group not only inhibited the release of insulin, but also affected the gastrointestinal peptide nerve fibers. Increased plasma concentrations of motilin in diabetic patients may be due to decreased motility of gastrointestinal motilin.