论文部分内容阅读
目的探讨母体麻疹抗体与婴儿麻疹发病关系,为降低婴儿麻疹发病,提供科学依据。方法对枣庄市1999-2011年婴儿麻疹发病状况及采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)对母体、婴儿、育龄妇女麻疹抗体调查分析。采用SPSS 11.5软件统计分析,分析方法采用χ2检验、t检验、F检验,以P<0.05为差异有统计学意义。结果 1999-2011年共发生麻疹1 485例,婴儿占38.45%;其中<8月龄占23.10%。2004年前(1999-2004年)后(2005-2011年),<8月龄婴儿麻疹所占比例分别为4.46%和30.59%;婴儿平均发病月龄分别为9.38月和7.65月,差异均有统计学意义(χ2=23.62、t=2.74,P均<0.01)。育龄妇女麻疹几何平均倒数滴度(GMRT)2001年最高,为675.50,2009年最低,为370.23;各年份间差异有统计学意义(F=10.78,P<0.01)。婴儿麻疹抗体阳性率、GMRT,2005和2009年6月龄与1999年8月龄相当,差异均无统计学意义(χ2=0.36、t=1.21,P均>0.05)。婴儿患与未患麻疹,其母体抗体阳性率、GMRT分别为79.88%,373.63;86.48%,510.85,差异均有统计学意义(χ2=5.44,P<0.05;t=4.21,P均<0.01)。结论母体麻疹抗体与婴儿麻疹密切相关,随母传麻疹抗体的提前消失婴儿发病月龄趋于前移。因此,提高母体麻疹抗体水平,是控制婴儿麻疹的根本措施。
Objective To investigate the relationship between maternal measles antibody and infant measles and to provide a scientific basis for reducing the incidence of measles in infants. Methods The incidence of measles in infants from 1999 to 2011 in Zaozhuang City and the detection of measles antibody in maternal, infant and childbearing age women by enzyme-linked immunosorbent assay (ELISA). Using SPSS 11.5 software statistical analysis, the analysis method using χ2 test, t test, F test, P <0.05 was considered statistically significant. Results A total of 1 485 measles cases were reported in 1999-2011, accounting for 38.45% of all infants. Among them, <8 months accounted for 23.10%. Before 2004 (1999-2004) (2005-2011), the proportion of measles in infants aged <8 months was 4.46% and 30.59%, respectively. The mean age at onset of infancy was 9.38 months and 7.75 months respectively Statistical significance (χ2 = 23.62, t = 2.74, P <0.01). The geometric mean reciprocal titre (GMRT) of measles in childbearing women was the highest in 2001 at 675.50 and the lowest in 2009 was 370.23. The difference was statistically significant among all the years (F = 10.78, P <0.01). The positive rate of measles antibody in infancy was GMRT. The levels of GMRT in 2005 and 2009 were similar to those of August 1999, and there was no significant difference (χ2 = 0.36, t = 1.21, P> 0.05). The prevalence of maternal antibody was 79.88%, 373.63; 86.48%, 510.85 in infants with or without measles, the difference was statistically significant (χ2 = 5.44, P <0.05; . Conclusion The maternal measles antibody is closely related to the measles in infants. With the early disappearance of the mother measles antibody, the age of onset of the infant tends to move forward. Therefore, raising the level of maternal measles antibody is the fundamental measure to control infant measles.