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目的 食管癌化疗序贯放疗和单纯放疗疗效对比研究。方法 ２４８ 例食管癌随机分为综合治疗组１２５ 例和单纯放疗组１２３ 例。综合组：ＤＤＰ（５０ｍｇｍ２ ，Ｄ１ ，８）５ＦＵ（７５０ｍｇｍ２ ，Ｄ２６） 静脉注射，３ 周为一周期，潘生丁５０ｍｇ，口服，每天三次。２３ 周期化疗后放疗（ＤＴ６０７０Ｇｙ６－５７－５周） 。单纯放疗组直接放疗（ＤＴ６０７０Ｇｙ６－５７－５ 周） 。结果 两组近期疗效无明显差别，综合组完全缓解率及１ ，３，５ 年生存率高于单纯放疗组（ｐ ＜ ０－０５） 。结论 化疗后序贯放疗是治疗食管癌安全有效的方法。
Objective To compare the efficacy of sequential radiotherapy and radiotherapy for esophageal cancer chemotherapy. Methods 248 cases of esophageal cancer were randomly divided into a comprehensive treatment group of 125 cases and 123 cases of radiotherapy alone. Comprehensive group: DDP (50mg m2, D1, 8) 5 FU (750mg m2, D2 6) intravenous injection, 3 weeks for a cycle, dipyridamole 50mg, orally, three times a day. Radiotherapy after 2-3 cycles of chemotherapy (DT60-70Gy6-5-7-5 weeks). Radiotherapy alone radiotherapy (DT60-70Gy6-5 7-5 weeks). Results There was no significant difference between the two groups in the short-term efficacy. The complete remission rate and the 1-, 3-, 5-year survival rate in the comprehensive group were higher than those in the radiotherapy alone group (p < 0-05). Conclusion Sequential radiotherapy after chemotherapy is a safe and effective method for the treatment of esophageal cancer.