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目的:观察血管内皮生长因子(VEGF)及连环蛋白p120在乳腺腺病和乳腺癌中的表达,探讨两者与乳腺癌临床病理特征的临床意义。方法:采用免疫组化SP法检测62例乳腺癌及26例乳腺腺病组织中VEGF和p120的表达情况。结果:乳腺癌组织中VEGF和p120的异常表达率分别为77.4%(48/62)和80.6%(50/62),与良性组相比差异有统计学意义,P=0.000。两者均与肿瘤病理分级和TNM分期相关,但均与肿瘤大小无相关。VEGF在有腋窝淋巴结转移的癌组织中阳性率明显高于无淋巴结转移者,P=0.017;p120表达情况和淋巴结转移无关,P=0.072。两者在乳腺癌组织中的表达具有正相关性,P=0.011。结论:VEGF及p120在乳腺癌组织中异常表达,并与乳腺癌浸润转移关系密切,是乳腺癌发生发展的生物学指标之一,联合检测对评估预后及临床治疗有指导意义。
OBJECTIVE: To observe the expression of vascular endothelial growth factor (VEGF) and c-protein p120 in breast adenosis and breast cancer, and to explore the clinical significance of both of them and clinicopathological features of breast cancer. Methods: The immunohistochemical SP method was used to detect the expression of VEGF and p120 in 62 cases of breast cancer and 26 cases of breast adenosis. Results: The abnormal expression rates of VEGF and p120 in breast cancer tissues were 77.4% (48/62) and 80.6% (50/62), respectively, which were significantly different from those in benign group (P = 0.000). Both were correlated with tumor pathological grade and TNM staging, but none correlated with tumor size. The positive rate of VEGF in cancer tissues with axillary lymph node metastasis was significantly higher than those without lymph node metastasis, P = 0.017; the expression of p120 had no correlation with lymph node metastasis (P = 0.072). There was a positive correlation between the two expressions in breast cancer tissues, P = 0.011. Conclusion: The abnormal expressions of VEGF and p120 in breast cancer tissues are closely related to the infiltration and metastasis of breast cancer. Therefore, VEGF and p120 are one of the biological indicators for the development of breast cancer. The combined detection of VEGF and p120 may be helpful for the evaluation of prognosis and clinical treatment.