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目的研究老年肺癌组织学特点及其Ｐ５３蛋白的表达。方法肺癌组织学类型按ＷＨＯ标准进行分类，Ｐ５３蛋白的表达采 用免疫组化技术。结果老年组肺癌的组织学类型与非老年组不同，差异有显著性（Ｐ＜０．０５）；Ｐ５３蛋白总阳性率为４２．８６％，两组间差 异没有显著性（Ｐ＞０．０５）。结论老年肺癌的组织学类型有其自己的特点，Ｐ５３基因在肺癌的发生发展中具有重要意义。
Objective To study the histological features and expression of P53 protein in lung cancer in elderly patients. Methods The histological types of lung cancer were classified according to the WHO criteria. The expression of P53 protein was performed using immunohistochemistry. Results The histological types of lung cancer in elderly patients were different from those in non-elderly patients (P<0.05). The total positive rate of P53 protein was 42.86%. There was no significant difference between the two groups (P>0.05). ). Conclusion The histological type of lung cancer in elderly patients has its own characteristics. P53 gene plays an important role in the development of lung cancer.