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以三氨基盐酸胍和乙酰丙酮为原料,关环得到3,6-二(3,5-二甲基-1H-吡唑-1-基)-1,2-二氢-1,2,4,5-四嗪(2),然后通过氧化、取代合成了三个新型的1,2,4,5-四嗪类衍生物,其结构经1 H NMR和MS表征。对化合物3,6-二(2-氨甲基吡啶基)-1,2,4,5-四嗪(4a)的X射线晶体衍射研究表明:其属于三斜晶系,P1空间群,晶胞参数为a=8.076 4(16),b=9.526 2(19),c=10.243(2),α=86.08(3)°,β=74.60(3)°,γ=69.87(3)°,V=713.1(2)3,Z=2,μ(Mo Kα)=0.092,F(000)=308.
Starting from guanidine trihydrochloride and acetylacetone, 3,6-bis (3,5-dimethyl-1H-pyrazol-1-yl) -1,2-dihydro-1,2,4 , 5-tetrazine (2). Three novel 1,2,4,5-tetrazine derivatives were synthesized by oxidation and substitution. Their structures were characterized by 1 H NMR and MS. X-ray crystallography of the compound 3,6-bis (2-aminomethylpyridyl) -1,2,4,5-tetrazine (4a) showed that it belongs to triclinic system, space group P1, The cell parameters were a = 8.076 4 (16) , b = 9.526 2 (19) , c = 10.243 (2) , α = 86.08 (3) °, β = 74.60 ) °, V = 713.1 (2) 3, Z = 2, μ (Mo Kα) = 0.092, F (000) = 308.